' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
USERS' SCORE
Good
Based on 9 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 benefits IBS in teens
Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial.
Highly relevant IBS vitamin D study
We aimed to understand how vitamin D3 supplementation might help adolescents suffering from irritable bowel syndrome (IBS), especially those who are deficient in vitamin D. Our study involved 112 adolescents diagnosed with IBS, who were split into two groups based on their age and gender.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
Read More
9
Vitamin D improves IBS symptoms
Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
Highly relevant to research question
We conducted a randomized, double-blind clinical trial to understand how vitamin D3 affects individuals with irritable bowel syndrome (IBS). Our study involved 90 IBS patients who received either 50,000 IU of vitamin D3 or a placebo every two weeks for six months. Throughout this period, participants tracked their symptoms and completed questionnaires about their quality of life related to their IBS.
The results were quite promising. We observed that those taking vitamin D3 reported significantly greater improvements in symptoms like abdominal pain, bloating, and gas compared to those receiving a placebo. Specifically, the scores evaluating the severity of IBS symptoms and the quality of life showed notable enhancements in the vitamin D group after the six-month treatment period.
This suggests that vitamin D has the potential not only to alleviate some uncomfortable IBS symptoms but also to improve overall quality of life for those affected. Our findings indicate that incorporating vitamin D3 could be a beneficial approach for managing IBS.
The results were quite promising. We observed that those taking vitamin D3 reported significantly greater improvements in symptoms like abdominal pain, bloating, and gas compared to those receiving a placebo. Specifically, the scores evaluating the severity of IBS symptoms and the quality of life showed notable enhancements in the vitamin D group after the six-month treatment period.
This suggests that vitamin D has the potential not only to alleviate some uncomfortable IBS symptoms but also to improve overall quality of life for those affected. Our findings indicate that incorporating vitamin D3 could be a beneficial approach for managing IBS.
Read More
8
Vitamin D3 shows promise for IBS
Vitamin D3 as a novel treatment for irritable bowel syndrome: single case leads to critical analysis of patient-centred data.
Directly addresses vitamin D3 effects
We explored the potential of high-dose vitamin D3 as a treatment for irritable bowel syndrome (IBS), a condition that significantly affects the quality of life for those who suffer from it. Our examination began with a compelling case of a 41-year-old woman who reported substantial improvements in her IBS symptoms after starting vitamin D3 supplementation.
Inspired by her experience, we gathered data from various social media platforms, where we found additional patient accounts regarding the effects of vitamin D on IBS. Our systematic analysis revealed that among 37 individuals discussing their outcomes, about 70% indicated that high-dose vitamin D supplementation helped alleviate their IBS symptoms.
While these findings suggest a positive response to vitamin D3, they highlight the need for more rigorous research. A randomised controlled trial could help confirm these observations and provide more concrete evidence on how vitamin D supplementation influences symptomatology in IBS patients.
Inspired by her experience, we gathered data from various social media platforms, where we found additional patient accounts regarding the effects of vitamin D on IBS. Our systematic analysis revealed that among 37 individuals discussing their outcomes, about 70% indicated that high-dose vitamin D supplementation helped alleviate their IBS symptoms.
While these findings suggest a positive response to vitamin D3, they highlight the need for more rigorous research. A randomised controlled trial could help confirm these observations and provide more concrete evidence on how vitamin D supplementation influences symptomatology in IBS patients.
Read More
Most Useful Reviews
6.3
Vitamin benefits noted
I highly recommend continuing vitamin intake, particularly for those with irritable bowel syndrome, as absorption can be poor. This vitamin D supplement from a reputable company offers essential support for gut health, which we often struggle to maintain.
Read More
9.5
Enhanced psychological state
Since taking this supplement, I feel much better. It positively affects my mood and helps my bones absorb calcium, which is beneficial for those of us with irritable bowel syndrome. It's fat-soluble, so it's best taken with high-fat foods.
Read More
8
Mood improvement noted
I’ve realised that vitamin D supports calcium exchange and even influences hair growth. Its deficiency often leads to issues like depression and muscle weakness. Given the pandemic, having adequate vitamin D is vital, especially for those with irritable bowel syndrome.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
9
Vitamin D3 benefits IBS in teens
Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial.
Highly relevant IBS vitamin D study
We aimed to understand how vitamin D3 supplementation might help adolescents suffering from irritable bowel syndrome (IBS), especially those who are deficient in vitamin D. Our study involved 112 adolescents diagnosed with IBS, who were split into two groups based on their age and gender.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
Read More
9
Vitamin D improves IBS symptoms
Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
Highly relevant to research question
We conducted a randomized, double-blind clinical trial to understand how vitamin D3 affects individuals with irritable bowel syndrome (IBS). Our study involved 90 IBS patients who received either 50,000 IU of vitamin D3 or a placebo every two weeks for six months. Throughout this period, participants tracked their symptoms and completed questionnaires about their quality of life related to their IBS.
The results were quite promising. We observed that those taking vitamin D3 reported significantly greater improvements in symptoms like abdominal pain, bloating, and gas compared to those receiving a placebo. Specifically, the scores evaluating the severity of IBS symptoms and the quality of life showed notable enhancements in the vitamin D group after the six-month treatment period.
This suggests that vitamin D has the potential not only to alleviate some uncomfortable IBS symptoms but also to improve overall quality of life for those affected. Our findings indicate that incorporating vitamin D3 could be a beneficial approach for managing IBS.
The results were quite promising. We observed that those taking vitamin D3 reported significantly greater improvements in symptoms like abdominal pain, bloating, and gas compared to those receiving a placebo. Specifically, the scores evaluating the severity of IBS symptoms and the quality of life showed notable enhancements in the vitamin D group after the six-month treatment period.
This suggests that vitamin D has the potential not only to alleviate some uncomfortable IBS symptoms but also to improve overall quality of life for those affected. Our findings indicate that incorporating vitamin D3 could be a beneficial approach for managing IBS.
Read More
8
Vitamin D3 enhances IBS treatment
Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut-Brain Axes in Physiology and IBS Syndrome.
Strong relevance to IBS research
We explored the effects of a novel form of Vitamin D3, known as VitD3-NS, on individuals suffering from irritable bowel syndrome (IBS). This Vitamin D3 was complexed within cyclodextrin nanosponges to enhance its solubility and stability, which is vital because these properties can significantly affect the vitamin's biological activity.
Our study examined how VitD3-NS interacts with both healthy and IBS-affected gut-brain axes. We observed that this innovative formulation was effective in mitigating damage caused by liposaccharides, a common inflammatory factor, in the gut. Specifically, when tested at a concentration of 100 ng/mL for 48 hours, VitD3-NS helped restore the viability and integrity of crucial cells called tight junctions. It also reduced markers of oxidative stress, such as reactive oxygen species and cytokines.
Following intestinal transit, we noticed improvements in neurodegenerative conditions for both healthy individuals and those with IBS. This suggests that the protective benefits of VitD3-NS are preserved even under challenging IBS conditions, boosting its efficacy by approximately 50%. Consequently, our findings indicate that this form of Vitamin D3 could provide significant support for gut health and overall well-being for those dealing with IBS.
Our study examined how VitD3-NS interacts with both healthy and IBS-affected gut-brain axes. We observed that this innovative formulation was effective in mitigating damage caused by liposaccharides, a common inflammatory factor, in the gut. Specifically, when tested at a concentration of 100 ng/mL for 48 hours, VitD3-NS helped restore the viability and integrity of crucial cells called tight junctions. It also reduced markers of oxidative stress, such as reactive oxygen species and cytokines.
Following intestinal transit, we noticed improvements in neurodegenerative conditions for both healthy individuals and those with IBS. This suggests that the protective benefits of VitD3-NS are preserved even under challenging IBS conditions, boosting its efficacy by approximately 50%. Consequently, our findings indicate that this form of Vitamin D3 could provide significant support for gut health and overall well-being for those dealing with IBS.
Read More
8
Vitamin D3 aids IBS management
Vitamin D and lactoferrin attenuate stress-induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR-STAT3 signaling and modulating autophagy.
Relevant study on vitamin D3
Exploring the impact of stress on irritable bowel syndrome (IBS), we investigated how vitamin D3 influences stress-induced colitis in Wistar rats. The study involved four groups: a control group, a group exposed to chronic stress, and two groups treated with vitamin D3 or lactoferrin after stress exposure.
We observed that both vitamin D3 and lactoferrin treatment showed positive effects. Specifically, rats receiving vitamin D3 experienced improvements in social interactions, reduced anxiety levels, and decreased inflammation markers compared to those that were only stressed. The treatment enhanced certain beneficial proteins related to autophagy, which is the process of clearing out damaged cells and maintaining healthy cell function.
Our findings suggest that vitamin D3 might play a role in supporting gut health and mitigating symptoms associated with IBS when faced with psychological stress. However, we noted that lactoferrin appeared to provide even greater benefits in this context, indicating it could be a more effective option for managing stress-induced colitis.
Overall, this research highlights the potential of vitamin D3 as a helpful supplement for those struggling with IBS, especially in stressful situations, while also recognizing the advantages of lactoferrin.
We observed that both vitamin D3 and lactoferrin treatment showed positive effects. Specifically, rats receiving vitamin D3 experienced improvements in social interactions, reduced anxiety levels, and decreased inflammation markers compared to those that were only stressed. The treatment enhanced certain beneficial proteins related to autophagy, which is the process of clearing out damaged cells and maintaining healthy cell function.
Our findings suggest that vitamin D3 might play a role in supporting gut health and mitigating symptoms associated with IBS when faced with psychological stress. However, we noted that lactoferrin appeared to provide even greater benefits in this context, indicating it could be a more effective option for managing stress-induced colitis.
Overall, this research highlights the potential of vitamin D3 as a helpful supplement for those struggling with IBS, especially in stressful situations, while also recognizing the advantages of lactoferrin.
Read More
8
Vitamin D3 may improve IBS-D symptoms
Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial.
Direct evaluation of vitamin D3
In a randomized, double-blind, placebo-controlled trial conducted with 74 patients suffering from diarrhea-predominant irritable bowel syndrome (IBS-D), we sought to examine the effects of vitamin D3 supplementation on their symptoms, quality of life, and certain biochemical markers. Participants were divided into two groups, one receiving 50,000 IU of vitamin D3 weekly, while the other received a placebo for a duration of nine weeks.
We observed that patients in the vitamin D3 group experienced significant improvements in symptom severity, quality of life, levels of depression and anxiety, and visceral sensitivity compared to those in the placebo group, with statistical significance in several areas.
However, it's worth noting that no significant changes were found in measurements of serum serotonin, 5-hydroxy-indole acetic acid, or the ratio between them between the two groups at the end of the study.
Our findings suggest that addressing vitamin D deficiency might be beneficial in managing IBS-D symptoms and enhancing the overall quality of life for affected individuals.
We observed that patients in the vitamin D3 group experienced significant improvements in symptom severity, quality of life, levels of depression and anxiety, and visceral sensitivity compared to those in the placebo group, with statistical significance in several areas.
However, it's worth noting that no significant changes were found in measurements of serum serotonin, 5-hydroxy-indole acetic acid, or the ratio between them between the two groups at the end of the study.
Our findings suggest that addressing vitamin D deficiency might be beneficial in managing IBS-D symptoms and enhancing the overall quality of life for affected individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.3
9.5
Enhanced psychological state
Since taking this supplement, I feel much better. It positively affects my mood and helps my bones absorb calcium, which is beneficial for those of us with irritable bowel syndrome. It's fat-soluble, so it's best taken with high-fat foods.
8.8
Improved gut health
Vitamin D3 is essential for those with autoimmune diseases who struggle to absorb it from food or sunlight. I've found it significantly helps manage my autoimmune condition and improves my bowel health, especially in addressing irritable bowel syndrome.
8.5
Quality product observed
I regularly order this supplement as the small capsules are easy to take. Vitamin D supports immunity and overall health, which is essential considering the various issues related to irritable bowel syndrome. The quality is excellent, and it promotes calcium absorption.
8.3
Bowel movements improved
I started taking this supplement upon a friend's recommendation, and it significantly improved my bowel movements. I'm happy to address my vitamin deficiency with it. The capsules are reasonably priced and easy to consume, although they tend to stick together in heat.
8
Mood improvement noted
I’ve realised that vitamin D supports calcium exchange and even influences hair growth. Its deficiency often leads to issues like depression and muscle weakness. Given the pandemic, having adequate vitamin D is vital, especially for those with irritable bowel syndrome.
